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Ane Marit Wagbo on Muck Rack

Ane Marit Wagbo

As seen in: BioRxiv
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Articles

Functional Impact of Nth-like DNA glycosylase on Mitochondrial Dynamics

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By Luisa Luna, Lisa Anne Hubers, Alexander Myr Sjetne, Ane Marit Wagbo
| BioRxiv
Abstract Nth-like DNA glycosylase (NTHL1) is a base excision repair enzyme, with a crucial role both in nuclear and mitochondrial genomic maintenance. In this study, we demonstrate a key function of NTHL1 on mitochondrial DNA (mtDNA) maintenance and mitochondrial dynamics. Our results reveal significant accumulation of mitochondrial transcripts and increased mtDNA levels in NTHL1-deficient cells, accompanied by an accumulation of mtDNA lesions.
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