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Angela Barrera

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Articles

Near‐Infrared Light Activated Formulation for the Spatially Controlled Release of CRISPR‐Cas9 Ribonucleoprotein for Brain Gene Editing

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By Susana MN Simoes, Miguel Ángel Lino, Angela Barrera, Catarina Rebelo
| Wiley Online Library Verified
Genome editing using clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated protein 9 (Cas9)1 has high potential for the treatment of neurological diseases originating from genetic mutations, including Alzheimer disease,2 Huntington disease,3 and amyotrophic lateral sclerosis,4 among others. Many of the advances made in CRISPR brain delivery systems have been achieved by taking advantage of viral vectors, specifically adeno-associated viruses (AAVs).
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