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Anicet Lugendo

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Articles

Rheumatoid arthritis-associated peptidylarginine deiminase 4 haplotype citrullinates human immunodeficiency virus-pol and confers antiviral activity

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By Mai Izumida, Reiko Miyahara, Su Han, Sho Shimada, Masataka Umeda, Tomohiro Koga, Atsushi Kawakami, Takeshi Tanaka, Anicet Lugendo
| Nature Verified
Abstract Peptidylarginine deiminase 4 (PADI4)-mediated citrullination modulates immune responses and drives autoantibody formation in rheumatoid arthritis (RA). Two common haplotypes, defined by four exonic SNPs (PADI4_89, 90, 92, and 104), have been described, with haplotype 2 (the risk haplotype associated with increased mRNA stability) conferring increased susceptibility to RA.
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