Anita Ruf on Muck Rack

Anita Ruf

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Articles

Mechanistic adaptation of the metazoan RabGEFs Mon1-Ccz1 and Fuzzy-Inturned

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By Jessica C. Hankins, Maik Drechsler, Lucie Laporte, Stephan Wilmes, Jan-Hannes Schafer, Jesse Tönjes, Anna Lürick, Dovile Januliene, Daniele Di Iorio, Seraphine V. Wegner, Martin Loose, Arne Moeller, Achim Paululat, Daniel Kümmel, Anita Ruf, Steven Apelt
| Science Magazine Verified
Abstract Rab GTPases organize intracellular trafficking and provide identity to organelles. Their spatiotemporal activation by guanine nucleotide exchange factors (GEFs) is tightly controlled to ensure fidelity. Our structural and functional comparison of the tri-longin domain RabGEFs Mon1-Ccz1 and Fuzzy-Inturned reveals the molecular basis for their target specificity.
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