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Bradykinin type 2 receptor deficiency alters vascular endothelial growth factor and atrial natriuretic peptide levels in early-stage diabetic retinopathy - Marin Radmilović, Helena Justić, Anja Barić, Martina Ratko, Iva Šimunić, Zoran Vatavuk, Aleksandra
Get full access to this article View all access and purchase options for this article. Data availability statement Key resources that are essential to reproduce the results are provided in the Supplemental Material (Supplemental Table 1). The raw data used and/or analyzed are available from the corresponding authors upon request. References 1. Cheung N, Mitchell P, Wong TY. Diabetic retinopathy. Lancet 2010; 376: 124–136. 2. Saaddine JB.
The temporal dynamic of bradykinin type 2 receptor effects reveals its neuroprotective role in the chronic phase of cerebral and retinal ischemic injury - Helena Justić, Anja Barić, Martina Ratko, Iva Šimunić, Marin Radmilović, Marta Pongrac, Siniša Škoki
Introduction Bradykinin (BK), a nonapeptide of the kallikrein-kinin system (KKS), is among the earliest inflammatory mediators released in response to cerebral and/or retinal ischemia.1–5 BK exerts its biological effects by activating two types of G-protein coupled receptors: a constitutive bradykinin type 2 receptor (B2R) and an inducible bradykinin type 1 receptor (B1R).6–10 The role of B2R in the initial stages of cerebral and retinal ischemia has been the subject of extensive research due...
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