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Anjelica Vance on Muck Rack

Anjelica Vance

As seen in: BioRxiv
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Articles

Testing of putative antiseizure drugs in a preclinical Dravet syndrome zebrafish model

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By Francisco Figueroa, Paige Whyte-Fagundes, Anjelica Vance, Aloe Carroll
| BioRxiv
Abstract Dravet syndrome (DS) is a severe genetic epilepsy primarily caused by de novo mutations in a voltage-activated sodium channel gene (SCN1A). Patients face life-threatening seizures that are largely resistant to available anti-seizure medications (ASM). Preclinical DS animal models are a valuable tool to identify candidate ASMs for these patients. Among these, scn1lab mutant zebrafish exhibiting spontaneous seizure-like activity are particularly amenable to large-scale drug screening.
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