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Langerhans Cell Histiocytosis in Children and Adults – An Interdisciplinary Diagnostic and Therapeutic Challenge
Langerhanszell-Histiozytose (LCH) ist eine seltene maligne Erkrankung, die überwiegend im Kindes-, aber auch im Erwachsenenalter auftritt. Die Erkrankung betrifft meist das Skelettsystem, die Haut oder die Hypophyse, kann aber fast jedes Organ befallen und so zu unterschiedlichsten Symptome führen. Zunehmende Kenntnisse der Pathophysiologie ermöglichen neue Therapieoptionen wie den Einsatz von RAF- oder MAP-Kinase-Inhibitoren.
Pneumocystis jirovecii pneumonia in paediatric acute lymphoblastic leukaemia: A report from the multi‐international clinical trial AIEOP‐BFM ALL 2009
INTRODUCTION Pneumocystis jirovecii can cause life-threatening pneumonia (PjP) and patients with haematological malignancies, or undergoing haematopoietic cell transplantation, are at an especially high risk of this infectious complication.1-3 Prophylactic measures such as the intermittent administration of trimethoprim/sulfamethoxazole (TMP/SMX) have significantly decreased morbidity and mortality due to this infection.4 There is, however, a paucity of contemporary data on the incidence and...
Nonculture Diagnostics in Invasive Fungal Infections in Children
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