Ann Elisabeth Åsberg on Muck Rack

Ann Elisabeth Åsberg

As seen in: Taylor & Francis Online
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Articles

Imperfect reference standards cause biased likelihood ratios

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By Arne Åsberg, Ann Elisabeth Åsberg
| Taylor & Francis Online
Abstract In a study of the diagnostic accuracy of a quantitative biomarker, the researcher compares the concentration of the biomarker in patients with and without the disease in question. The diagnosis must be set without knowledge of the biomarker concentration, using the best reference standard available. If the reference standard is not perfect, the estimates of the receiver operating characteristic (ROC) curves will be biased.
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