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Anna AM Ahlback on Muck Rack

Anna AM Ahlback

As seen in: BioRxiv
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Articles

The synovial lining macrophage layer develops in the first weeks of life in a CSF1- and TGFβ- dependent but monocyte-independent process.

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By Marlene Pinto, Bert Malengier-Devlies, Anna AM Ahlback, Guillaume Seuzaret
| BioRxiv
Abstract Synovial joints harbor a protective lining layer, consisting of fibroblasts and macrophages, which form an epithelial-like barrier. In inflamed joints, lining macrophages regulate both early inflammatory cell influx and resolution. Despite these critical functions, it is currently unknown at what stage during development the synovial macrophage lining is established, and which signals drive this process.
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Intestinal helminth skews DC2 development towards regulatory phenotype to counter the anti-helminth immune response.

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By Anna Andrusaite, Holly Webster, Olivia J Ridgewell, Anna AM Ahlback
| BioRxiv
Abstract The intestinal immune system maintains a balance between active immunity needed for protection and tolerance towards harmless antigens. Dendritic cells (DCs) found in the intestinal mucosa are key to the adaptive arm of these immunoregulatory events. DCs sample antigens in the tissue and then migrate to the draining lymph nodes, where they prime the T cells that then migrate back to the tissue as effector or regulatory cells.
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