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Articles by Anna Constance Vind
Mechanism of RACK1-dependent ZAKα activation at stalled and collided ribosomes
ArticleVolume 86, Issue 12p2341-2357.e10Open access Affiliations & Notes 1Center for Gene Expression, Department of Cellular and Molecular Medicine, University of Copenhagen, Blegdamsvej 3, 2200 Copenhagen, Denmark 2Department of Molecular Biology and Genetics, Aarhus University, Aarhus, Denmark 3Randall Centre for Cell and Molecular Biophysics, King’s College London, London SE1 1UL, UK 4Center for Integrative Genomics, University of Lausanne, 1015 Lausanne, Switzerland Article Info...
Death by ribosome
Keywords ribotoxic stress response ZAKα pyroptosis apoptosis self-inflicted ribotoxicity Get full text access Log in, subscribe or purchase for full access. References 1. Shore, D. ∙ Albert, B. Ribosome biogenesis and the cellular energy economy Curr. Biol. 2022; 32:R611-R617 2. Vind, A.C. ... Run, ribosome, run: from compromised translation to human health Antioxid. Redox Signal. 2023; 39:336-350 3.
The ribotoxic stress response drives acute inflammation, cell death, and epidermal thickening in UV-irradiated skin in vivo
Keywords UV skin ribotoxic stress response ZAK-alpha pyroptosis apoptosis inflammation p38 JNK Introduction Skin separates the organism from its surroundings and provides a barrier against the external environment, trauma, and infection. In this capacity, the skin is also the most exposed part of our body and is constantly challenged with radiation, chemical irritants, and thermal fluctuations.
“Homo est deus”: Reflections on Luther's Christology
1 INTRODUCTION Lately, Luther's Christology has been a hot topic within research.
ROS-induced ribosome impairment underlies ZAKα-mediated metabolic decline in obesity and aging
Published In Science Volume 382 | Issue 6675 8 December 2023 Article versions Submission history Received: 13 October 2022 Accepted: 3 November 2023 Published in print: 8 December 2023 Permissions Request permissions for this article. Acknowledgments We thank P. Rengtved Lundegaard (University of Copenhagen, Denmark) for help with zebrafish work, X. Lu (Jinan University, China) for the kind gift of ZAK inhibitors, V.
Mechanistic basis for nigericin-induced NLRP1 inflammasome activation in human epithelial cells
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Computational and Functional Analysis of Structural Features in the ZAKα Kinase
Abstract : The kinase ZAKα acts as the proximal sensor of translational impairment and ribotoxic stress, which results in the activation of the MAP kinases p38 and JNK. Despite recent insights into the functions and binding partners of individual protein domains in ZAKα, the mechanisms by which ZAKα binds ribosomes and becomes activated have remained elusive.
Ribosome stalling is a signal for metabolic regulation by the ribotoxic stress response
Antibodies Mouse monoclonal anti-phospho-p38 Cell Signaling Cat#9216; RRID: AB_331296 Rabbit monoclonal anti-phospho-p38 Cell Signaling Cat#4511S; RRID: AB_2139682 Mouse polyclonal antibody anti-p38 Cell Signaling Cat#9212; RRID: AB_330713 Mouse monoclonal anti-phospho-SAPK/JNK Cell Signaling Technology Cat#9255; RRID: AB_2307321 Rabbit monoclonal anti-SAPK/JNK Cell Signaling Cat#9258; RRID: AB_2141027 Rabbit polyclonal anti-ZAK Proteintech Cat#14945-1-AP; RRID: AB_1064269 Rabbit polyclonal...
ZAKα Recognizes Stalled Ribosomes through Partially Redundant Sensor Domains
Highlights • ZAKα binds directly to the ribosome and is the proximal sensor of ribotoxic stress • ZAKα contains two partially redundant domains for sensing ribotoxic stress • Constitutive activation of ZAKα is associated with developmental defects in humans • Deficiency in the ribotoxic stress response compromises lifespan in C.
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