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Anna Karolina Palucka on Muck Rack

Anna Karolina Palucka

As seen in: The Journal of Immunology
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Cancer cell-derived transforming growth factor (TGF)-β and myeloid cell-derived interleukin (IL)-1β synergize to promote type 2 inflammation and breast cancer progression

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By Jacques Banchereau, Te-Chia Wu, Kangling Xu, Anna Karolina Palucka
| The Journal of Immunology Verified
Human breast cancer displays type 2 inflammation that promotes cancer progression and can be linked with interleukin (IL)-13 signature. The underlying molecular mechanisms include cancer-derived thymic stromal lymphopoietin (TSLP). Here, we found that IL-13 correlates with high levels of IL-1β in primary breast cancers. IL-1β levels correlate with disease stage indicating association with cancer invasiveness.
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