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Articles by Anna Lasorella
Acquired genetic and cell-state changes in IDH-mutant glioma progression
Abstract Gliomas with mutant isocitrate dehydrogenase (IDH) are malignant brain tumours that typically arise in early to mid-adulthood and nearly always recur following treatment1,2. However, the genetic and cellular-state changes that drive IDH-mutant glioma progression under treatment remain incompletely understood.
Restraint of cancer cell plasticity by spatial homotypic clustering
Keywords cancer cell plasticity glioblastoma intratumor heterogeneity single-cell spatial transciptomic single-cell spatial proteomics tumor ecosystem Introduction Aggressiveness and therapy resistance in cancer have been attributed to intratumor heterogeneity, a hallmark of malignant tumors initially inferred by transcriptome analysis of bulk tumors and clearly defined by the studies of the transcriptome of single cells.1,2,3,4 Molecular heterogeneity is fueled by plasticity, a feature...
Deciphering the longitudinal trajectories of glioblastoma ecosystems by integrative single-cell genomics - Nature Genetics
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Abstract The evolution of isocitrate dehydrogenase (IDH)-wildtype glioblastoma (GBM) after standard-of-care therapy remains poorly understood. Here we analyzed matched primary and recurrent GBMs from 59 patients using single-nucleus RNA sequencing and bulk DNA sequencing, assessing the longitudinal evolution of the GBM ecosystem across layers of cellular and molecular heterogeneity.
By Kevin Johnson, Masashi Nomura, Luciano Garofano, Djamel Nehar-Belaid, Noam Galili Darnell, Lillian Bussema, Frederick S. Varn, Fulvio D’Angelo, Kevin Anderson, Nicolas Robine, Catherine Reeves, Anuja Lipsa, Anna Golebiewska, Simone P Niclou, Sun Ha Paek, Franck Bielle, Alice Laurenge, Bertrand Mathon, David Ashley, Keith L. Ligon, Jason T. Huse, Anna Lasorella, Antonio Iavarone, Itay Tirosh
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Nature
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The making of the glioblastoma classification
Summary Classification of cancer should lead to informative patients’ stratification and selective therapeutic vulnerabilities. A pathway-based classification of glioblastoma uncovered a mitochondrial subtype with a unique sensitivity to inhibitors of oxidative phosphorylation. Precision targeting of cancer metabolism could provide therapeutic opportunities to a lethal neoplasm and be translated to other tumour types. Fig. 1: Four-group functional classification of glioblastoma. References 1.
Some Brain Tumors May Respond to Immunotherapy, New Study Suggests
Immunotherapy has proved effective in treating a number of cancers, but brain tumors have remained stubbornly resistant. Now, a new study suggests that a slow-growing brain tumor arising in patients affected by neurofibromatosis type 1 (NF1) may be vulnerable to immunotherapy, which gives the immune system a boost in fighting cancer.
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