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BACKGROUND Implementation of lung cancer screening (LCS) in high-risk individuals reduces the risk of dying from lung cancer. The mortality benefit of LCS, however, can only be fully actualized in patients who adhere to follow-up screening examinations. Question: Does a centralized program offer better adherence to lung cancer screening compared with a decentralized approach?
Research in context Evidence before the study We searched PubMed for articles published up to Dec 20, 2021, using the terms “vaccine effectiveness waning” or “vaccine booster” and “COVID-19”. We found reviews summarising that titres of binding and neutralising antibodies wane over time for all vaccines and that this is also applicable to COVID-19 vaccines.
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