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Anna Navarro Figueredo on Muck Rack

Anna Navarro Figueredo

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Articles

Stromal cell senescence augments haematopoietic cell fitness in clonal haematopoiesis

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By Jayna Mistry, Kira Young, Gibran Edun, Alicia G. Aguilar-Navarro, Patricia Diaz, Patricia Díaz Verified, Maria Telpoukhovskaia, Ines Fernandez Maestre, Sheng Cai, Katharina Götze, Anastasia Tikhonova, Ross Levine, Jennifer J. Trowbridge, Anna Navarro Figueredo
| Nature Verified
Abstract Microenvironment remodelling impacts tumour growth and metastasis, but whether remodelling promotes pre-malignant clonal fitness remains unknown. Here, using single-cell RNA-sequencing of the bone-marrow microenvironment in a mouse model of DNMT3A-mutant clonal haematopoiesis (CH), we identify mesenchymal stromal cells (MSCs) in a molecular state of cellular senescence. Elevated bone-marrow MSC senescence is also observed in humans with CH driven by several common somatic mutations.
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