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Anna Normann Bak on Muck Rack

Anna Normann Bak

As seen in: BioRxiv
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Articles

TDP-43 pathology is sufficient to drive axon initial segment plasticity and hyperexcitability of spinal motoneurones in vivo in the TDP43-ΔNLS model of Amyotrophic Lateral Sclerosis

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By Svetlana Djukic, Zhenxiang Zhao, Dennis Jensen, Anna Normann Bak
| BioRxiv
Abstract A hyperexcitability of the motor system is consistently observed in Amyotrophic Lateral Sclerosis (ALS) and has been implicated in the disease pathogenesis. What drives this hyperexcitability in the vast majority of patients is unknown. This is important to know as existing treatments simply reduce all neuronal excitability and fail to distinguish between pathological changes and important homeostatic changes.
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