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Anna Pia Enblad on Muck Rack

Anna Pia Enblad

As seen in: Nature, BioRxiv
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Articles

An integrative molecular map of pediatric B-cell precursor acute lymphoblastic leukemia

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By Olga Krali, Anna Pia Enblad, Dea Gogishvili, Anders Lundmark, Arja Harila, Claes Andersson, Tom Erkers, Merja Heinäniemi, Gudmar Lönnerholm, Jessica Nordlund, Julia Sulyaeva
| Nature Verified
Abstract The molecular landscape of pediatric B-cell precursor acute lymphoblastic leukemia (BCP-ALL) has been extensively characterized through single-modality studies. However, the interplay between molecular modalities and their collective influence on treatment response and outcomes remains poorly understood. We integrated genomic, epigenomic, transcriptomic, and ex vivo drug response data from 1231 patients diagnosed with BCP-ALL.
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Mapping the Spatial Proteome of Leukemia Cells Undergoing Fludarabine Treatment

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By Henrik Gezelius, Anna Pia Enblad, Anders Lundmark, Maria Ascencion Globisch
| BioRxiv
Abstract Recent advancements in spatial biology have revolutionized our understanding of the organization and functional dynamics of cells and tissues. In this study, we applied Molecular Pixelation (MPX), a single-cell spatial proteomics assay, to investigate the modulation of the cell surface proteome in an in vitro drug screening model using the ETV6::RUNX1 acute lymphoblastic leukemia (ALL) cell line, Reh .
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COMPARISON OF HIGH-THROUGHPUT SINGLE-CELL RNA-SEQ METHODS FOR EX VIVO DRUG SCREENING

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By Anders Lundmark, Henrik Gezelius, Anna Pia Enblad, Martin Aberg
| BioRxiv
Abstract Functional precision medicine (FPM) aims to optimize patient-specific drug selection based on the unique characteristics of their cancer cells. Recent advancements in high throughput ex vivo drug profiling have accelerated interest in FPM.
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