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Anna S. Trigos on Muck Rack

Anna S. Trigos

As seen in: Nature, Genome Biology, BioRxiv
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Articles

Recurrent intra-tumour heterogeneity is a hallmark of metastatic prostate cancer

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By Yangyi Zhang, Timothy Semple, Luciano G Martelotto, Catherine Mitchell, Richard Young, Benjamin Blyth, Yuzhou Feng, Heather Thorne, Roslyn Wallace, Joanna Chan, Julia Como, Lisa Devereux, Himisha Beltran, Daniel Wetterskog, Scott Williams, Anthony T. Papenfuss, Belinda S. Parker, Paul Neeson, Gerhardt Attard, David Quigley Verified, David Goode, Richard Pearson, Luc Furic, Anna S. Trigos, Shahneen Sandhu, Sirui Weng, Lachlan Cain, James Comben, Sara Alaei, David Yoannidis, Anupama Pasam, Joy Hendley
| Nature Verified
Abstract The evolution to metastatic disease is a major determinant of cancer mortality. Cancer evolution involves a complex interplay between intrinsic genetics and transcriptional alterations and the microenvironment.
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Disruption of metazoan gene regulatory networks in cancer alters the balance of co-expression between genes of unicellular and multicellular origins - Genome Biology

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By Anna S. Trigos, Felicia Bongiovanni, Yangyi Zhang, Richard W. Tothill, Richard Pearson, Anthony T. Papenfuss, David Goode, Maia Zethoven
| Genome Biology Verified
We used phylostratigraphy [6] to determine the evolutionary ages of genes, as we have previously done [5]. Briefly, human genes were mapped onto a phylogenetic tree of 16 phylostrata based on sequence similarity, spanning genes found across all organisms (phylostratum 1) to those specific to humans (phylostratum 16). Genes with orthologs in bacteria or single-cell eukaryotes (clades 1–3) were designated as having unicellular origins (UC genes).
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Copy number architectures define treatment-mediated selection of lethal prostate cancer clones - Nature Communications

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By Paolo Cremaschi, Daniel Wetterskog, Anna S. Trigos, Blanca Trujillo, Marina A. Parry, Mazlina Ismail, Wout Devlies, Cristina Naceur-Lombardelli, Charles Swanton, Mariam Jamal-Hanjani
| Nature Verified
Patients and rapid warm post-mortem program Of the ten patients involved in this study (median age 69 with a range of 56–72 years, all male), nine participated in a community-based rapid autopsy (Cancer Tissue Collection After Death, CASCADE) program described previously31 and the remaining one patient participated in the Cancer Research UK Posthumous Evaluation of Advanced Cancer Environment (PEACE, NCT03004755) program.
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