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Allergic rhinitis caused by grass pollen affects a quarter of the UK population [1]. Of these, around 5 million people suffer moderate-severe persistent symptoms that have an impact on quality of life, including disturbed sleep, disruption of leisure activities and impairment of performance at work/school [2]. Therefore, there is a substantial unmet need for both therapy and prophylaxis of seasonal allergic rhinitis.
Chronic rhinosinusitis (CRS) is one of the most common chronic diseases in the UK, with an estimated prevalence of 10.4%. CRS has been shown to have a significant impact on quality of life, worse in some domains of the Short Form-36 than COPD or angina. It carries a high socioeconomic burden; with estimated healthcare costs in the USA of $772/patient/year (2011). Untreated, CRS may also cause exacerbation of co-existing asthma.
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