Anna Yang
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Articles by Anna Yang
Limiting antihypertensive use does not reduce mortality in nursing home residents with frailty
1. In this randomized clinical trial, among older nursing home residents with frailty who were being treated for hypertension with at least two antihypertensive agents, an antihypertensive medication step-down strategy was not found to have a significant effect on all-cause mortality. 2. Secondary outcomes, including major adverse cardiovascular events and measures of functional capacity, were also similar between the two groups.
Presymptomatic treatment of spinal muscular atrophy with risdiplam leads to improved functional outcomes
1. In this single-group trial, among infants predicted to develop type 1 spinal muscular atrophy (SMA) who were treated presymptomatically with risdiplam within the first six weeks after birth, most had the ability to sit up within 12 months, which would not be possible for most untreated infants. 2. These infants also survived without assisted ventilation and achieved appropriate motor milestones over a period of 24 months, which would not be attainable with supportive care alone.
Ciprofloxacin is non-inferior to aminoglycoside-ciprofloxacin for bubonic plague treatment
1. In this randomized controlled trial, among patients with bubonic plague, oral ciprofloxacin monotherapy was found to be noninferior to sequential treatment with an injectable aminoglycoside followed by oral ciprofloxacin with respect to incidence of treatment failure. 2. The percentages of patients with a serious adverse event or nonserious adverse event were similar between the two groups.
Trastuzumab deruxtecan leads to longer overall survival than ramucirumab plus paclitaxel in HER2-positive gastric cancer
1. In this randomized controlled trial, among adults with HER2-positive unresectable or metastatic gastric cancer who had previously progressed on trastuzumab-based therapy, it was found that trastuzumab deruxtecan resulted in longer overall survival than ramucirumab plus paclitaxel. 2. The overall incidence of adverse events was similar between the two groups, although trastuzumab deruxtecan was associated with a greater risk of interstitial lung disease or pneumonitis.
Tirzepatide leads to greater weight loss than semaglutide among adults with obesity
1. In this randomized controlled trial, among adults with obesity, it was found that tirzepatide resulted in a significantly greater reduction in body weight and waist circumference than semaglutide. 2. Adverse events led to treatment discontinuation more often in the semaglutide group than in the tirzepatide group.
In Response to Factors Associated With Hearing‐Related Quality of Life in Children With Hearing Loss
Data Availability Statement The data that support the findings of this study are available from the corresponding author upon reasonable request.
Tumor-infiltrating clonal hematopoiesis is associated with NSCLC recurrence
1. In this retrospective cohort study, the presence of tumor-infiltrating clonal hematopoiesis (TI-CH) was associated with an increased risk of disease recurrence or death among patients with non-small-cell lung cancer (NSCLC). 2. Using preclinical mouse and organoid models of lung cancer, TI-CH was found to remodel the tumor immune microenvironment and accelerate tumor organoid growth.
Evolution of a landslide‐dammed lake during the Holocene: Records from lacustrine and fan‐delta successions in southeastern Tibet
Supporting Information Filename Description esp70104-sup-0001-Suppl_materials.docxWord 2007 document , 80 KB Figure S1 (A) and (B) Natural OSL and IRSL signal decay curves of XQ-3 and XQ-11, respectively. REFERENCES , , & (2001) Bedforms and associated sedimentary structures formed under supercritical water flows over aggrading sand beds. Sedimentology, 48(1), 133–152. Available from: https://doi.org/10.1046/j.1365-3091.2001.00357.x & (1988) Lacustrine varve formation through time.
Twice-yearly lenacapavir prevents HIV more effectively than daily F/TDF
1. In this randomized controlled trial, among men and gender-diverse persons who have sex with men, it was found that twice-yearly lenacapavir resulted in a significantly lower human immunodeficiency virus (HIV) incidence than with daily F/TDF. 2. The incidence of adverse events and laboratory abnormalities was similar between the two groups.
Stanford's Title IX office took two years to suspend rapist
Content warning: This article contains references to sexual violence. A source included in this story asked to remain anonymous for fear of retaliation. A pseudonym is used to improve readability. The Daily is also withholding specific dates, instead using general timeframes, to protect the identity of the source. In her sophomore fall, Amy and her friend attended a party. As she was visibly drunk, an acquaintance offered to walk her back to her dorm while her friend stayed.
Factors Associated With Hearing‐Related Quality of Life in Children With Hearing Loss
Objective Our objective was to determine how hearing-related quality of life (HEAR-QL) varies with time and explore its association with hearing loss (HL) characteristics in children aged 7–18 years old. Study Design Retrospective chart review. Methods Medical records of 7–18 year-olds with HL who completed ≥ 1 HEAR-QL questionnaire were reviewed. Longitudinal HEAR-QL changes were explored using mixed linear models. Results Data from 109 children with HL were analyzed.
Factors Associated With Hearing‐Related Quality of Life in Children With Hearing Loss
Objective Our objective was to determine how hearing-related quality of life (HEAR-QL) varies with time and explore its association with hearing loss (HL) characteristics in children aged 7–18 years old. Study Design Retrospective chart review. Methods Medical records of 7–18 year-olds with HL who completed ≥ 1 HEAR-QL questionnaire were reviewed. Longitudinal HEAR-QL changes were explored using mixed linear models. Results Data from 109 children with HL were analyzed.
Tezepelumab alleviates symptoms in severe chronic rhinosinusitis with nasal polyps
1. In this randomized controlled trial, among patients with severe, uncontrolled chronic rhinosinusitis with nasal polyps, tezepelumab more effectively reduced nasal polyp size and sinonasal symptoms compared to placebo. 2. Tezepelumab led to greater reductions in the use of nasal polyp surgery and systemic glucocorticoids compared to placebo.
Seven days of antibiotic treatment non-inferior to 14 days for bloodstream infections
1. In this randomized controlled trial, among hospitalized patients with a bloodstream infection, seven days of antibiotic treatment was found to be noninferior to 14 days of treatment with respect to death from any cause within 90 days. 2. Rates of antimicrobial-related adverse outcomes, Clostridioides difficile infections, and secondary infection with antibiotic-resistant organisms were similar between the seven-day and 14-day groups.
Remibrutinib alleviates symptoms in chronic spontaneous urticaria resistant to H1-antihistamines
1. In this randomized controlled trial, among patients with chronic spontaneous urticaria who continue to have symptoms while on second-generation H1-antihistamines, it was found that remibrutinib more effectively reduced itching and hives compared with placebo. 2. Adverse events among patients who received remibrutinib were generally similar to those in the placebo group, with most adverse events being mild or moderate.
DoE letter warns Stanford about campus antisemitism
In a Monday letter, the U.S. Department of Education’s (DoE) Office for Civil Rights (OCR) warned the University of “potential enforcement actions” if they did not fulfill obligations under Title VI of the Civil Rights Act to protect Jewish students on campus. Stanford is one of 60 institutions that received the letter, which was addressed to all universities currently under investigation for Title VI violations relating to antisemitic harassment and discrimination.
Education Department letter warns Stanford about campus antisemitism
In a Monday letter, the U.S. Department of Education’s (ED) Office for Civil Rights (OCR) warned the University of “potential enforcement actions” if they did not fulfill obligations under Title VI of the Civil Rights Act to protect Jewish students on campus. Stanford is one of 60 institutions that received the letter, which was addressed to all universities currently under investigation for Title VI violations relating to antisemitic harassment and discrimination.
Intraosseous and intravenous vascular access are equally effective for ROSC following out-of-hospital cardiac arrest
1. In this randomized clinical trial, among patients who had an out-of-hospital cardiac arrest, no significant difference was found in sustained return of spontaneous circulation between intraosseous and intravenous vascular access. 2. Rates of survival and survival with a favorable neurologic outcome at 30 days were also similar between the two groups. Evidence Rating Level: 1 (Excellent) Study Rundown: Out-of-hospital cardiac arrest is a common event that is associated with high mortality.
Mpox cases in Africa continued to increase following WHO emergency declarations
1. The number of mpox cases in Africa increased leading up to the first mpox declaration of a Public Health Emergency of International Concern (PHEIC) by the World Health Organization (WHO), and this trend continued to worsen following the emergency declarations. 2. The highest burden of mpox in Africa has been in the Democratic Republic of Congo (DRC), which continued to report an increasing number of weekly mpox cases in 2024.
Plozasiran reduces triglyceride levels and acute pancreatitis incidence in persistent chylomicronemia
1. In this randomized controlled trial, among patients with persistent chylomicronemia, it was found that plozasiran more effectively reduced fasting triglyceride and apolipoprotein C-III levels, as well as acute pancreatitis incidence, compared with placebo. 2. Adverse events among patients who received plozasiran were generally similar to those in the placebo group, with severe adverse events being more common in the placebo group.
Levofloxacin does not prevent infection in children exposed to MDR tuberculosis
1. In this randomized controlled trial, among children and adolescents with household exposure to an adult with multidrug-resistant tuberculosis, it was found that levofloxacin did not result in a significantly lower incidence of infection compared with placebo. 2. Preventive treatment with levofloxacin was not associated with any safety concerns, with the levofloxacin and placebo groups having similarly low proportions of participants with serious adverse events.
Nexiguran ziclumeran reduces serum TTR levels in transthyretin amyloid cardiomyopathy
1. In this phase one clinical trial, among patients with transthyretin amyloid cardiomyopathy (ATTR-CM), it was found that nexiguran ziclumeran (nex-z), a CRISPR-Cas9 therapy that targets TTR, is associated with significant and sustained reductions in serum transthyretin (TTR) levels. 2.
Daily reporter to face no disciplinary action from Stanford
Stanford has dropped the disciplinary case against Daily reporter Dilan Gohill ’27, according to an email from President Jon Levin ’94 obtained by the Daily. Gohill had been detained last June while covering the occupation of Building 10 by pro-Palestinian protesters.
Free speech organizations call for Levin’s support of Daily reporter
The First Amendment Coalition (FAC) and the Student Press Law Center (SPLC) called on President Jon Levin ’94 to voice support for Daily reporter Dilan Gohill ’27 as he faces potential charges by the Santa Clara County District Attorney’s Office. Gohill was detained in June on suspicion of felony burglary, vandalism and conspiracy while covering the occupation of Building 10 by pro-Palestinian protesters.
Collagenase injection is not noninferior to fasciectomy for Dupuytren’s contracture treatment
1. In this randomized controlled trial, among patients with moderate Dupuytren’s contracture, collagenase injection was not found to be noninferior to limited fasciectomy in improving patient-reported hand health. 2. Collagenase injection resulted in a lower percentage of patients with moderate to severe complications compared with limited fasciectomy.
Stereotactic body radiotherapy is noninferior to hypofractionated radiotherapy for localized prostate cancer
1. In this randomized controlled trial, among patients with localized prostate cancer, five-fraction stereotactic body radiotherapy (SBRT) was found to be noninferior to conventionally or moderately hypofractionated radiotherapy for biochemical or clinical failure. 2.
Stereotactic body radiotherapy is noninferior to hypofractionated radiotherapy for localized prostate cancer
1. In this randomized controlled trial, among patients with localized prostate cancer, five-fraction stereotactic body radiotherapy (SBRT) was found to be noninferior to conventionally or moderately hypofractionated radiotherapy for biochemical or clinical failure. 2.
Beta-blocker interruption not noninferior to continuation following myocardial infarction
1. In this randomized controlled trial, among patients with a history of myocardial infarction (MI), interruption of long-term beta-blocker therapy was not found to be noninferior to beta-blocker continuation in preventing death, MI, stroke, and hospitalization for cardiovascular reasons. 2. Interruption of long-term beta-blocker therapy did not improve patient-reported quality of life compared with beta-blocker continuation.
Beta-blocker interruption not noninferior to continuation following myocardial infarction
1. In this randomized controlled trial, among patients with a history of myocardial infarction (MI), interruption of long-term beta-blocker therapy was not found to be noninferior to beta-blocker continuation in preventing death, MI, stroke, and hospitalization for cardiovascular reasons. 2. Interruption of long-term beta-blocker therapy did not improve patient-reported quality of life compared with beta-blocker continuation.
Tulisokibart effectively induces clinical remission in moderately to severely active ulcerative colitis
1. In this randomized controlled trial, among patients with moderately to severely active ulcerative colitis, tulisokibart, a monoclonal antibody directed against TL1A, more effectively induced clinical remission compared with placebo. 2. Compared with placebo, the tulisokibart group consistently showed benefits in clinical response, endoscopic improvement, histologic improvement, symptomatic remission, and inflammatory biomarkers.
Tulisokibart effectively induces clinical remission in moderately to severely active ulcerative colitis
1. In this randomized controlled trial, among patients with moderately to severely active ulcerative colitis, tulisokibart, a monoclonal antibody directed against TL1A, more effectively induced clinical remission compared with placebo. 2. Compared with placebo, the tulisokibart group consistently showed benefits in clinical response, endoscopic improvement, histologic improvement, symptomatic remission, and inflammatory biomarkers.
Oxygen therapy for 15 versus 24 hours per day does not change hypoxemia-related mortality
1. In this randomized controlled trial, among patients with severe hypoxemia, long-term oxygen therapy used for 24 hours per day resulted in no reduction in risk of hospitalization or death within one year compared with oxygen therapy for 15 hours per day. 2. Oxygen therapy for 15 versus 24 hours per day was associated with similar patient-reported scores for fatigue, health status, and perceived overall well-being.
Oxygen therapy for 15 versus 24 hours per day does not change hypoxemia-related mortality
1. In this randomized controlled trial, among patients with severe hypoxemia, long-term oxygen therapy used for 24 hours per day resulted in no reduction in risk of hospitalization or death within one year compared with oxygen therapy for 15 hours per day. 2. Oxygen therapy for 15 versus 24 hours per day was associated with similar patient-reported scores for fatigue, health status, and perceived overall well-being.
Plozasiran reduces triglyceride levels in mixed hyperlipidemia
1. In this randomized controlled trial, among patients with mixed hyperlipidemia, plozasiran significantly reduced fasting triglyceride levels compared with placebo. 2. Compared with placebo, the plozasiran groups also saw reductions in apolipoprotein C3 (APOC3), non-high-density lipoprotein (HDL) cholesterol, and apolipoprotein B (apoB) levels.
Adjunctive treatment with argatroban or eptifibatide does not improve post-stroke functional outcomes
1. In this randomized controlled trial, among ischemic stroke patients treated with intravenous thrombolysis, it was found that adjunctive intravenous argatroban or eptifibatide did not reduce disability 90 days post-stroke compared with placebo. 2. Symptomatic intracranial hemorrhage did not occur more frequently among patients treated with adjunctive intravenous argatroban or eptifibatide.
Adjunctive treatment with argatroban or eptifibatide does not improve post-stroke functional outcomes
1. In this randomized controlled trial, among ischemic stroke patients treated with intravenous thrombolysis, it was found that adjunctive intravenous argatroban or eptifibatide did not reduce disability 90 days post-stroke compared with placebo. 2. Symptomatic intracranial hemorrhage did not occur more frequently among patients treated with adjunctive intravenous argatroban or eptifibatide.
The Protective Efficacy of a SARS-CoV-2 Vaccine Candidate B.1.351V against Several Variant Challenges in K18-hACE2 Mice
The emergence of SARS-CoV-2 variants of concern (VOCs) with increased transmissibility and partial resistance to neutralization by antibodies has been observed globally. There is an urgent need for an effective vaccine to combat these variants. Our study demonstrated that the B.1.351 variant inactivated vaccine candidate (B.1.351V) generated strong binding and neutralizing antibody responses in BALB/c mice against the B.1.351 virus and other SARS-CoV-2 variants after two doses within 28 days.
The Protective Efficacy of a SARS-CoV-2 Vaccine Candidate B.1.351V against Several Variant Challenges in K18-hACE2 Mice
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Police Blotter: Motor vehicle burglary, hit-and-run and vandalism
This report covers a selection of incidents from May 13 to May 21 as recorded in the Stanford University Department of Public Safety (SUDPS) bulletin. Learn more about the Clery Act and how The Daily approaches reporting on crime and safety here. Petty theft between 8 a.m. on May 10 and 9 a.m. on May 13 was reported at 757 Campus Drive (EVGR Building A). Vandalism of less than $400 at 2:50 p.m. was reported at 751 Olmsted Road (Madera Child Care Center).
Police Blotter: Hate violence, motor vehicle theft and vandalism
This report covers a selection of incidents from May 6 to May 12, as recorded in the Stanford University Department of Public Safety (SUDPS) bulletin. Learn more about the Clery Act and how The Daily approaches reporting on crime and safety here. Vandalism of less than $400 at 3 p.m. on May 3 was reported at 350 Jane Stanford Way (Packard Building). Disorderly conduct involving alcohol between 8:45 p.m. and 11 p.m. was reported at 29 Olmsted Road (Escondido Village Building 29).
Stanford to review Biden's revised Title IX regulations
Content warning: This article contains references to sexual violence. The Biden Administration released revised Title IX regulations on Apr. 19, impacting policies across educational settings. The main changes include increased protections for LGBTQ+ students and sexual assault survivors. These changes, which Stanford and all universities are required to implement, will take effect on Aug. 1.
Stanford surveys students on sexual misconduct and awareness
Content warning: This article contains references to sexual violence. The Higher Education Sexual Misconduct and Awareness (HESMA) survey launches on April 30, wrote University Provost Jenny Martinez in a Monday announcement to students. The purpose of the survey, which is filled out by students across ten participating universities, is to “assess the prevalence of sexual assault” at Stanford and “understand student perceptions of Stanford’s climate around these issues,” Martinez wrote.
OpenAI CEO Sam Altman talks AI development and society
Sam Altman, OpenAI’s co-founder and CEO, faced a crowd of students in NVIDIA Auditorium who met him with questions and an enthusiastic rendition of happy birthday. Over one thousand people lined up outside of Jen-Hsun Huang Engineering Center to get a chance to attend Altman’s speaker event, which was hosted by the Stanford Engineering Entrepreneurship Center (STVP) as part of the Entrepreneurial Thought Leaders (ETL) Seminar on Wednesday — three days after the 39 year old’s birthday.
'Take Back the Night' raises awareness on sexual violence
Content warning: This article includes references to sexual violence. Around 100 students and Stanford affiliates assembled in Meyer Green on Tuesday night to participate in Take Back the Night (TBTN), an event hosted across several college campuses, with the hope to raise awareness about sexual violence and create space for survivors to share experiences.
Faculty Senate debates undoing Scott Atlas censure
Jonathan Levin ’94 made his first remarks as incoming president to the Faculty Senate on Thursday, at a meeting where the Senate continued to debate reversing the 2020 censure of Scott Atlas, a Hoover Institution senior fellow. Levin thanked the Presidential Search Committee, President Richard Saller and the Senate. “Every single day I get to walk on the campus and I still feel that same sense of possibility that I felt the first time I walked into this campus when I was 17,” he said.
Annual sexual assault and harassment reports decrease by 18.2%, six employees terminated
Content warning: This article contains references to sexual violence. Sexual assault and harassment reports decreased by 18.2% over the past academic year and six employees were terminated, according to the 2022-23 Title IX/Sexual Harassment Annual Report published last Thursday.
Quantitation of Enterovirus A71 Empty and Full Particles by Sedimentation Velocity Analytical Ultracentrifugation
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Green Library extends hours post ASSU advocacy
After months of discussion with the University, numerous student testimonials and a University-wide survey, ASSU Senators Ivy Chen ’26 and Gordon Allen ’26 successfully extended Green Library’s hours for the next 3 years. The Undergraduate Senate (UGS) and Graduate Student Council (GSC) both passed resolutions in support of extended library hours in February, before receiving notification of administration approval via email in late March, Chen said.
Brake the cycle: SUDPS enforces bike traffic laws
Campus police have become stricter about bike safety and traffic laws over the past few weeks, patrolling bike hotspots like Arrillaga Family Dining Commons, outside Stern and Roble Hall. According to a 2020 Daily analysis of Stanford Department of Public Safety (SUDPS) data, over 300 bike accidents were reported on campus between January 2014 and December 2018.
Ph.D. student testifies before Congress on antisemitism at Stanford
Kevin Feigelis, a seventh-year physics Ph.D. student at Stanford and an organizer involved with the Blue and White Tent, urged Congress to investigate campus antisemitism at a bipartisan roundtable hosted by the House Committee on Education and the Workforce last Thursday. “I’ve watched my campus transform from an idyllic paradise — a center of learning — into a wasteland of hatred where every interaction is a minefield,” he said in his opening remarks to the committee.
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