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Serum Neurofilament Light Chain Is Not an Independent Predictor of Autonomic Neuropathy in Hereditary Transthyretin Amyloidosis

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By Milou Berends, Johan Bijzet, Charlotte Teunissen, Anne Floor Brunger
| preprints.org
Submitted: 04 November 2025 You are already at the latest version Serum neurofilament light chain (sNfL) is a biomarker for peripheral neuropathy as sNfL correlates with polyneuropathy severity in hereditary transthyretin (ATTRv) amyloidosis. It is unclear whether sNfL also correlates with autonomic neuropathy. In this study, we aimed to predict the presence of autonomic neuropathy in patients with ATTRv amyloidosis based on sNfL levels.
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