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Pyrrolidine dithiocarbamate accelerates early recovery of intestinal microvascular oxygenation in a reversible model of hemorrhagic shock in rats - Journal of Translational Medicine
All experiments were approved by the local Animal Care and Use Committee (Landesamt für Natur, Umwelt und Verbraucherschutz, Recklinghausen, Germany, AZ. 81-02.04.2018.A308) and performed in accordance with the ARRIVE guidelines for animal care. Animals were derived from the animal research facility of the Heinrich-Heine-University Duesseldorf (ZETT, Zentrale Einrichtung für Tierforschung und wissenschaftliche Tierschutzaufgaben) and bred for experimental purposes.
Gemfibrozil Improves Microcirculatory Oxygenation of Colon and Liver without Affecting Mitochondrial Function in a Model of Abdominal Sepsis in Rats
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
IJMS | Free Full-Text | Pravastatin Improves Colonic and Hepatic Microcirculatory Oxygenation during Sepsis without Affecting Mitochondrial Function and ROS Production in Rats
3. Discussion In the past, several clinical and experimental studies reported a protective effect of statins in the state of sepsis, even if the level of evidence remains weak [12,13,28,29]. However, the exact mechanisms leading to the observed protective effects are still not fully understood. The results regarding the impact of statins on mitochondrial function have not been fully elucidated either and are even now controversially discussed.
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