Annibale Puca on Muck Rack

Annibale Puca

As seen in: MDPI, Science Magazine
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Articles

Special Issue “Centenarians-A Model to Study the Molecular Basis of Lifespan and Healthspan 2.0”

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By Calogero Caruso, Annibale Puca, Annibale Alessandro
| MDPI
1. State of the Art The global population is experiencing an increase in ageing and life expectancy. The substantial increase in life expectancy, accompanied by the ensuing ageing of the population, stands as a remarkable human achievement.
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Genetic Signatures of Exceptional Longevity in Humans

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By Paola Sebastiani, Nadia Solovieff, Annibale Puca, Stephen W. Hartley
| Science Magazine Verified
Healthy aging is thought to reflect the combined influence of environmental factors (lifestyle choices) and genetic factors. To explore the genetic contribution, we undertook a genome-wide association study of exceptional longevity (EL) in 1055 centenarians and 1267 controls. Using these data, we built a genetic model that includes 150 single-nucleotide polymorphisms (SNPs) and found that it could predict EL with 77% accuracy in an independent set of centenarians and controls.
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