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Annica Barizza on Muck Rack

Annica Barizza

As seen in: Nature, BioRxiv
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Articles

CD300e modulates metabolic programs in adipose tissue macrophages during obesity

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By Sara Coletta, Simone Pizzini, Stefania Vassallo, Elisabetta Trevellin, Annica Barizza, Sofia Giacometti, Gabriele Sales, Mattia Laffranchi, Silvano Sozzani, Marta Murgia, Agnese De Mario, Cristina Mammucari, Fabrizia Carli, Camilla Bean, Amalia Gastaldelli, Roberto Vettor, Marina de Bernard
| Nature Verified
Abstract Previous studies in monozygotic twins discordant for body mass index (BMI) revealed that individuals with obesity exhibit elevated expression of the immune receptor CD300e in white adipose tissue (WAT). Notably, CD300e levels decreased following weight loss, implicating its involvement in adipose tissue remodeling and metabolic regulation. To elucidate the functional role of CD300e, we employed a Cd300e knockout (Cd300e−/−) mouse model subjected to a high-fat diet (HFD).
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CD300e as a Driver of Immunosuppressive Tumor Microenvironment in Colorectal Cancer

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By Laura Masatti, Silvia Lonardi, Annica Barizza, Stefania Vassallo
| BioRxiv
Abstract Tumor-associated macrophages (TAMs) are the predominant immune population within the tumor microenvironment (TME), playing a key role in promoting tumor growth and establishing an immunosuppressive environment that facilitate immune evasion. Here we report that the immune receptor CD300e is highly expressed by TAM in colorectal (CRC) and drives their immunosuppressive and pro-tumorigenic, correlating with reduced expression of MHC-II molecules, essential for antigen presentation.
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