Annick Barbaud

BAT basophil activation test CGMP current good manufacturing practice CMC carboxymethylcellulose DHR drug hypersensitivity reaction DPT drug provocation test EAACI European Academy of Allergy and Clinical Immunology EDTA ethylenediaminetetraacetic acid EHR electronic health record EMA European Medicines Agency ENDA European Network for Drug Allergy FDA Food and Drug Administration GRADE Grading of Recommendations Assessment, Development and Evaluation IDT intradermal test IM intramuscular IV...

Hypersensitivity reactions to biologicals are increasingly reported; however, pediatric data on their immunopathogenesis, diagnosis, and management remain limited. This review summarizes the current evidence on clinical phenotypes, underlying mechanisms, and practical diagnostic and therapeutic strategies in children, highlighting the central role of allergy workup and tailored approaches such as premedication, drug provocation testing, and desensitization.

AGEP acute generalized exanthematous pustulosis Anti-TB antituberculosis ASA aspirin BAT basophil activation test BL beta-lactams COX cyclo-oxygenase CR cross-reactive CS corticosteroids DH drug hypersensitivity DHR drug hypersensitivity reactions DPT drug provocation test DRESS drug reaction with eosinophilia and systemic symptoms HS hypersensitivity IDT intradermal test Ig immunoglobulin IR immediate reaction IV intravenous MPE maculopapular exanthema NIR non-immediate reaction NSAIDs...