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Ansar Lee-Sam

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Articles

Late-stage functionalization with strain-release warheads enables tunable covalent inhibition

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By Nathan R. Zemke, Zoë Grant, Yubao Cheng, Zachary Shultz, Yun-Pu Chang, Luxin Sun, Alessio Gabellini, Kyle Pedretty, Thomas Scattolin, Victoria Izumi, Bin Fang, Samer Sansil, Lukasz Wojtas, John M. Koomen, Ernst Schönbrunn, Andrii Monastyrskyi, Derek R. Duckett, Justin M. Lopchuk, Ansar Lee-Sam, Dylan Grassie, Ramu Kakumanu
| Science Magazine Verified
Editor’s summary Structured Abstract Abstract Supplementary Materials References and Notes Information & Authors Metrics & Citations Check Access References Figures Tables Media Share Editor’s summary Covalent inhibitors are a class of molecules that has gained increased attention as approaches to improve the target selectivity of these drugs have advanced. However, off-target reactions can occur if the drug molecule’s electrophilic warhead is too reactive. Shultz et al.
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