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Ansi Chang on Muck Rack

Ansi Chang

As seen in: The Lancet
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Articles

Cortical neuronal densities and cerebral white matter demyelination in multiple sclerosis: a retrospective study

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By Bruce Trapp, Megan Vignos, Jessica Dudman, Ansi Chang
| The Lancet Verified
Demyelination of cerebral white matter is thought to drive neuronal degeneration and permanent neurological disability in individuals with multiple sclerosis. Findings from brain MRI studies, however, support the possibility that demyelination and neuronal degeneration can occur independently. We aimed to establish whether post-mortem brains from patients with multiple sclerosis show pathological evidence of cortical neuronal loss that is independent of cerebral white-matter demyelination.
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