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Anthonieke Middelman on Muck Rack

Anthonieke Middelman

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Articles

Maternal serotonin transporter genotype influences offspring’s anxiety-like behavior through prenatal and early postnatal routes

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By Rogério Castro, Paola Brivio, Weizhuo Li, Xianzong Meng, Qiuyuan Fang, Deborah Peeters, Roël M. Vrooman, Rick Greupink, Marcia Spoelder, Tianhua Wang, Markus Wöhr, Ling Shan, Chunqing Liu, Jan Buitelaar, Francesca Calabrese, Judith R Homberg, Sabrina I. Hanswijk, Brianna N. Natale, Sylvia Docq, Lisa C. M. W. Heltzel, Celine A. J. Smits, Marloes J. A. G. Henckens, Anthonieke Middelman, Petra H. H. van den Broek, Marta C. F. Samina, Michel M. M. Verheij, Sharon M. Kolk
| Nature Verified
Abstract Maternal serotonin transporter (5-HTT) genotype has been linked to offspring’s risk for neuropsychiatric disorders, yet the contribution of prenatal versus early postnatal routes remains unresolved. We combined a 5-HTT−/− rat model with a fostering procedure to disentangle these effects. 5-HTT+/− offspring genotype was kept constant by crossing 5-HTT−/− or 5-HTT+/+ dams with males of opposite genotypes.
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