Article highlights Aclidinium/formoterol 400/12 µg twice-daily has a safety profile comparable with its monotherapies and has been shown to improve lung function, health-related quality of life (HRQoL), and respiratory symptoms, as well as reducing exacerbation rates versus monotherapies and/or placebo in patients with moderate-to-severe chronic obstructive pulmonary disease (COPD) [16–19 Singh D, Jones PW, Bateman ED, et al.