Anthony H Tsang

ArticleVolume 38, Issue 5p876-890.e13Open access Affiliations & Notes 1Institute of Metabolic Science-Metabolic Research Laboratories, University of Cambridge, Cambridge, UK 2Department of Internal Medicine, Center for Hypothalamic Research, University of Texas Southwestern Medical Center at Dallas, Dallas, TX, USA 3Department of Pharmacology, University of Cambridge, Cambridge, UK Article Info Publication History: Received June 24, 2025; Revised October 3, 2025; Accepted March 27, 2026;...

Tamoxifen preparation and administration Tamoxifen was prepared in corn oil by sonication at 37 °C at 30 mg/ml prior to administration by oral gavage at 300 mg/kg on 4 consecutive days in Opalin-Cre/ERT2;Ai9 mice, or through the intraperitoneal at 80 mg/kg for 8 consecutive days in Plp-Cre/ERT2 mice.

Conclusions and clinical implications This review analysed interventions directly addressing parents’ needs with managing their CYP’s anxiety and/or depression, synthesising seven outcomes post-intervention and three at follow-up. A reduction in parental/carer anxiety at post-intervention favouring intervention (between-group study designs) with the exclusion of an influential case was the only significant effect. Between-study heterogeneity was low for majority of the analyses.