Anton Öberg Sysojev

1 Introduction Comorbidities are common in persons with multiple sclerosis (MS) and several, such as inflammatory bowel disease, epilepsy, depression, and anxiety, appear to be more common in persons with MS than in the general population [1]. Some comorbidities have also been linked to general disability progression, with the strongest evidence for depression and epilepsy [2].

Introduction Although current treatment guidelines recommend starting patients newly diagnosed with rheumatoid arthritis (RA) on methotrexate (MTX) [1], actual treatment response and subsequent outcome remain highly variable [2]. To facilitate early identification of treatment responders, recent attention has been given to the development of machine learning models supporting the prediction of MTX treatment outcomes among patients with RA.

INTRODUCTION Patients with rheumatoid arthritis (RA) are at increased risk of various comorbid conditions.1-3 Of these, cardiovascular disease (CVD) is among the most prevalent, with studies suggesting a 50% increased risk of CVD incidence among patients with RA compared to the general population.4, 5 Although CVD risk factors are more prevalent among patients with RA than the general population, such factors do not alone explain the entirety of the excess risk,6, 7 leading researchers to...