Anuj Kumar

Immunotherapy has been a promising treatment strategy for most of the cancers. (109) In general, PCa tumors are characterized as ‘cold’ due to lower expression of PD-L1 (transmembrane protein on T-cells), hindering the effect of current immunotherapy. Several methods were known to show modest improvements in the outcome of survival in patients.

Abstract The cytoskeletal protein plays a major role in various cellular processes. Understanding the interactions of small molecules with cytoskeletal protein therefore might help in the development of therapeutics. Employing combined molecular docking, all-atom molecular dynamics (MD) and infrequent well-tempered metadynamics (iWT-MetaD) we studied bacterial inhibitor A22 and actin protein interaction.

Abstract The Rnf complex is the primary respiratory enzyme of several anaerobic prokaryotes that transfers electrons from ferredoxin to NAD+ and pumps sodium ions (Na+) across a membrane, powering ATP synthesis. Rnf is widespread in primordial organisms and the evolutionary predecessor of the Na+-pumping NADH-quinone oxidoreductase (Nqr)1.