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Abstract This study evaluated once-daily oral dosing of Travelan (IMM-124E), a bovine polyclonal antibody product, for prevention of Enterotoxigenic Escherichia coli (ETEC)-induced diarrhoea. In this randomised, double-blind, placebo-controlled trial using an ETEC-controlled human infection model, 60 healthy subjects received 1200mg Travelan or placebo once-daily for 7 days. Two days after dosing commenced, subjects were challenged with ETEC strain H10407 and monitored for diarrhoeal symptoms.
Submitted: 03 December 2025 You are already at the latest version This paper introduces a Hybrid Intelligence Framework (HIF) for human-AI collaboration in the analysis of complex biological and behavioural datasets. HIF combines generative-AI pattern surfacing with subject-matter-expert (SME) curation to support transparent, auditable interpretation in small, multivariate studies.
Abstract The use of bacterial spores in probiotics over viable loads of bacteria has many advantages, including the durability of spores, which allows spore-based probiotics to effectively traverse the various biochemical barriers present in the gastrointestinal tract.
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