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Aphinya Suroengrit on Muck Rack

Aphinya Suroengrit

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Articles

Halogenated Chrysins Inhibit Dengue and Zika Virus Infectivity

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By Aphinya Suroengrit, Wanchalerm Yuttithamnon, Pimsiri Srivarangkul, Saran Pankaew
| Nature Verified
Previous studies suggested flavone and flavanone derivatives are promising flaviviral inhibitors10,11,12,13,14,20,21. In this study, we selected 8 flavonoid derivatives (Fig. 1) and tested their effect on DENV2 NGC in a LLC/MK2 cell-based system. Briefly, the compounds at final concentrations of 10??M and 25??M in DMSO were added to DENV2 infected LLC/MK2 cells and the effect on viral particle production was measured by plaque titration of the culture supernatants.
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