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1 INTRODUCTION Single domain von Willebrand factor type C (SVWC or SVC; called Vago in Drosophila) proteins in lower eukaryotes represent a family of secreted proteins having 8 instead of 10 cysteine residues found in the VWC domain resulting in the loss of a bond pair in the typical 10-cysteine VWC motif (www.ncbi.nlm.nih.gov/Structure/cdd/PF15430).

1 INTRODUCTION Eukaryotic protein kinases (EPKs) are highly dynamic, ATP (adenosine 5′-triphosphate)-dependent enzymes that catalyze phosphorylation of their downstream protein-substrates, thus acting as “switches” of signaling pathways with pivotal role in regulating key processes in human cells.

The derivation of integral fluxes from instrument coincidence rates requires accurate knowledge of their effective energies. Recent cross-calibrations of GOES with the high-energy-resolution IMP-8 Goddard Medium Energy Experiment (GME) [Sandberg et al., Geophys. Res. Lett, 41, 4435, 2014a] gave significantly lower effective energies than those currently used by the NOAA Space Weather Prediction Center to calculate solar proton integral fluxes from GOES rates.