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Arabela Ritchie

As seen in: BioRxiv
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Articles

Mass Generation and Long-term Expansion of Hepatobiliary Organoids from Adult Primary Human Hepatocytes

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By Ary Marsee, Adam Myszczyszyn, Shicheng Ye, Arabela Ritchie
| BioRxiv
Abstract Adult primary human hepatocytes (PHHs) are the gold standard in ex vivo toxicological studies and possess the clinical potential to treat patients with liver disease as advanced therapy medicinal products (ATMPs). However, the utility of this valuable cell type has been limited by short-term functionality and limited expansion potential in vitro.
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