Arad Ranji Jafroodi on Muck Rack

Arad Ranji Jafroodi

As seen in: Nature
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Articles

Investigation of the effects of sodium butyrate on SH-SY5Y neurons treated with amyloid beta42 and lipopolysaccharide: A computational and experimental study

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By Seyedeh Niloufar Rajaei, Mohammad Mehdi Alinaghi, Fatemeh Dashti, Mahtab Mehboodi, Mohammad Maleki, Atefeh Rahimi, Payam Baziyar, Vida Arabhalvaei, Mehrshad Talebi, Seyedeh Fatemeh Abachi, Zahra Khodayar, Arad Ranji Jafroodi, Mohammad Jamalaldin
| Nature Verified
Abstract Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by amyloid beta42 (Aβ42) aggregation, neuroinflammation, and synaptic dysfunction. This study combines computational and experimental approaches to investigate the neuroprotective effects of sodium butyrate (NaB). Differentiated SH-SY5Y neurons were exposed to lipopolysaccharide (LPS) and Aβ₁₋₄₂ to model AD-like conditions, and the potential protective effects of NaB were evaluated.
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