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Arata Komatsubara on Muck Rack

Arata Komatsubara

As seen in: BioRxiv
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Articles

Delayed localization of A-type lamins to the rupture sites in Hutchinson-Gilford progeria syndrome

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By Yohei Kono, Chan-Gi Pack, Takehiko Ichikawa, Arata Komatsubara
| BioRxiv
Abstract The nuclear lamina (NL) lines the nuclear envelope (NE) to maintain nuclear structure in metazoan cells. The major NL components, the nuclear lamins contribute to the protection against NE rupture induced by mechanical stress. Lamin A (LA) and a short form of the splicing variant lamin C (LC) are diffused from the nucleoplasm to sites of NE rupture in immortalized mouse embryonic fibroblasts (MEFs).
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Comprehensive analysis of A-type lamin tail region for repairing the nuclear lamina

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By Yohei Kono, Chan-Gi Pack, Takehiko Ichikawa, Arata Komatsubara
| BioRxiv
Abstract The nuclear lamina (NL) lines the inner nuclear membrane (INM) of the nuclear envelope (NE) to maintain nuclear structure in metazoan cells. The major NL components, the nuclear lamins contribute to the protection against NE rupture induced by mechanical stress. Lamin C (LC) but not lamin A (LA) is rapidly diffused from the nucleoplasm to sites of NE rupture induced by laser microirradiation in immortalized mouse embryonic fibroblasts (MEFs).
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