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Reference #1 Abstract Supplementary Materials REFERENCES AND NOTES eLetters (0) Information & Authors Metrics & Citations Check Access References Figures Tables Media Share This article has 0 eLetter . Abstract Dengue is the canonical viral disease for which immune history is a determinant of protective versus pathogenic responses and immunogenicity.
1 Introduction Flavin-dependent halogenases (FDHs) use FADH2, O2, and Cl− to generate HOCl, which travels down a 10 Å tunnel to halogenate aromatic substrates via electrophilic aromatic substitution [1-4] (Figure ). These bacterial and fungal biosynthetic enzymes are attractive for green chemistry applications because they regioselectively synthesize aryl halides under mild reaction conditions.
Abstract Dengue viruses (DENV1–4) are the most prevalent arboviruses in humans and a major public health concern. Understanding immune mechanisms that modulate DENV infection outcome is critical for vaccine development.
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