Archisman Banerjee

Abstract Acute myeloid leukemia (AML) presents significant clinical challenges due to patient heterogeneity and variable treatment responses. Cytogenetic and mutation-based biomarkers dominate current prognostic classifications. However, many patients lack these canonical markers, and most are not therapeutic targets. Gene expression-based biomarkers, despite their clinical potential, remain underexplored.

Abstract Glioblastoma (GBM) has a dismal median survival of 15 months owing to therapy resistance and inevitable recurrence. Using our cellular models of GBM radiation resistance, we had shown that GBM recurrence is due to survival and proliferation of residual disease cells enriched in multinucleated giant cells (MNGCs). However, MNGC division mechanism remained elusive. Here, using live-cell imaging we found daughter cells emerge from MNGCs by cytoplasmic pinching.