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Articles

Transfection-capable polycationic nanovectors which include PEGylated-cyclodextrin structural units. A new synthesis pathway.

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By Andrei Dascalu, Ardeleanu Rodinel, Andrei Neamtu, Stelian Maier
| Royal Society of Chemistry Verified
Efficient tools are still searched to substitute the viral vectors in nucleic acids delivery applications. One of the most severe constraint in producing them is related to the strict reproducibility of their molecular characteristics, ensured by synthesis. In this work, we report an original route to obtain polycationic nanoentities with low variability, able to act as cooperating carriers, for dsDNA complexation and transport.
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