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Ares Rocanin Arjo on Muck Rack

Ares Rocanin Arjo

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Articles

Wnt1 silences chemokine genes in dendritic cells and induces adaptive immune resistance in lung adenocarcinoma

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By Dimitra Kerdidani, Panagiotis Chouvardas, Ioanna Giopanou, Ares Rocanin Arjo
| Nature Verified
Abstract Lung adenocarcinoma (LUAD)-derived Wnts increase cancer cell proliferative/stemness potential, but whether they impact the immune microenvironment is unknown. Here we show that LUAD cells use paracrine Wnt1 signaling to induce immune resistance. In TCGA, Wnt1 correlates strongly with tolerogenic genes. In another LUAD cohort, Wnt1 inversely associates with T cell abundance.
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