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Arhit Chakrabarti on Muck Rack

Arhit Chakrabarti

As seen in: BioRxiv
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Articles

Disruption of Circadian Clock Induces Abnormal Mammary Morphology and Aggressive Basal Tumorigenesis by Enhancing LILRB4 Signaling

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By Olajumoke Ogunlusi, Mrinmoy Sarkar, Arhit Chakrabarti, Devon Boland
| BioRxiv
Abstract Epidemiological studies have shown that circadian rhythm disruption (CRD) is associated with the risk of breast cancer. However, the role of CRD in mammary gland morphology and aggressive basal mammary tumorigenesis and the molecular mechanisms underlying CRD and cancer risk remain unknown. To investigate the effect of CRD on aggressive tumorigenesis, a genetically engineered mouse model that recapitulates the human basal type of breast cancer was used for this study.
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Circadian rhythm disruption alters mammary gland morphology and accelerates cold aggressive tumorigenesis through a LILRB4-dependent pathway

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By Mrinmoy Sarkar, Olajumoke Ogunlusi, Arhit Chakrabarti, Devon Boland
| BioRxiv
Abstract Epidemiological studies have shown that circadian rhythm disruption (CRD) caused by shift work or frequent jet lag is associated with the risk of breast cancer development. However, the role of CRD in mammary gland morphology and aggressive mammary tumorigenesis and the molecular mechanisms underlying CRD and cancer risk remain unknown.
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