Ari Sudwarts on Muck Rack

Ari Sudwarts

As seen in: Nature, medRxiv
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Articles

PICALM Alzheimer’s risk allele causes aberrant lipid droplets in microglia - Nature

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By Ari Sudwarts, Hanwen Zhang, Seul Kee Byeon, Xiaotong Sun, Xin He, Julie Schneider, Akhilesh Pandey, Zhiping P. Pang, Alan R. Sanders, Hugo J. Bellen, Gopal Thinakaran, Christina Thapa
| Nature
Abstract Despite genome-wide association studies (GWAS) of late-onset Alzheimer’s disease (LOAD) having identified many genetic risk loci1,2,3, the underlying disease mechanisms remain largely unclear. Determining causal disease variants and their LOAD-relevant cellular phenotypes has been a challenge.
Open in Who Shared Issue with article?

Alzheimer's disease protective allele of Clusterin modulates neuronal excitability through lipid-droplet-mediated neuron-glia communication

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By Xiaojie Zhao, Siwei Zhang, Hanwen Zhang, Ari Sudwarts
| medRxiv
The authors have declared no competing interest. This work was supported by National Institute on Aging grants R01AG063175 (J.D. and G.T.), R01AG081374 (J.D.), RF1AG079141 (G.T.), R01 AG073260 (H.J.B.), and U01 AG072439 (H.J.B. and Josh Shulman). A.S. and L.D.G. are supported by BrightFocus fellowships. The work is also partially supported by National Institute of Mental Health grants R01MH116281 and R01MH106575 (J.D.).
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