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Abstract High-grade serous ovarian carcinoma (HGSOC) is marked by genomic instability, therapeutic resistance, and frequent relapse. Patient-derived xenograft (PDX) models are widely used in HGSOC research, yet the determinants of successful engraftment and molecular fidelity remain incompletely understood. We established subcutaneous HGSOC PDX models from 30 patients and integrated clinical, genomic, transcriptomic, immune, and geometric network analyses. The engraftment rate was 46.7%.
As a journalist, you can create a free Muck Rack account to customize your profile, list your contact preferences, and upload a portfolio of your best work.
