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Ariel Sobarzo on Muck Rack

Ariel Sobarzo

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Articles

Tumor-intrinsic transcriptional programs influence engraftment of high-grade serous ovarian carcinoma patient-derived xenografts

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By Rena Elkin, Sharon Davidesko, Mihai Meirovitz, Jung Hun Oh, Larry Norton, Roy Kessous, Maha Msamra, Ariel Sobarzo, Anastasia Agbaria, Darya Appel, Sarya Natour, Bertha Delgado
| Nature Verified
Abstract High-grade serous ovarian carcinoma (HGSOC) is marked by genomic instability, therapeutic resistance, and frequent relapse. Patient-derived xenograft (PDX) models are widely used in HGSOC research, yet the determinants of successful engraftment and molecular fidelity remain incompletely understood. We established subcutaneous HGSOC PDX models from 30 patients and integrated clinical, genomic, transcriptomic, immune, and geometric network analyses. The engraftment rate was 46.7%.
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