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Arig Ibrahim-Hashim on Muck Rack

Arig Ibrahim-Hashim

As seen in: Color Research & Application, Nature, PLOS ONE
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Articles

Immunomodulatory and pro-oncologic effects of ketamine and isoflurane anesthetics in a murine model

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By Dominique Abrahams, Arig Ibrahim-Hashim, Robert S. Ackerman, Morsani College
| PLOS ONE
Citation: Abrahams D, Ibrahim-Hashim A, Ackerman RS, Brown JS, Whelan CJ, Garfinkel MB, et al. (2023) Immunomodulatory and pro-oncologic effects of ketamine and isoflurane anesthetics in a murine model. PLoS ONE 18(10): e0292492. https://doi.org/10.1371/journal.pone.0292492 Editor: Syed M. Faisal, University of Michigan Medical School, UNITED STATES Received: June 26, 2023; Accepted: September 21, 2023; Published: October 10, 2023 Copyright: © 2023 Abrahams et al.
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Artificial selection for host resistance to tumour growth and subsequent cancer cell adaptations: an evolutionary arms race

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By Robert Gillies, Robert A. Gatenby, Arig Ibrahim-Hashim, Kimberly A Luddy
| Nature Verified
Abstract Background Cancer progression is governed by evolutionary dynamics in both the tumour population and its host. Since cancers die with the host, each new population of cancer cells must reinvent strategies to overcome the host’s heritable defences. In contrast, host species evolve defence strategies over generations if tumour development limits procreation.
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Hypoxia and Acidosis: Immune Suppressors and Therapeutic Targets

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By Arig Ibrahim-Hashim, Pedro M. Enriquez-Navas, Shari Pilon-Thomas, Robert Gillies, Albert Guvenis
| Color Research & Application Verified
Due to imbalances between vascularity and cellular growth patterns, the tumor microenvironment harbors multiple metabolic stressors including hypoxia and acidosis, which have significant influence on remodeling both tumor and peritumoral tissues. These stressors are also immunosuppressive and can contribute to escape from immune surveillance.
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