Arnau Solé Casaramona

The Journal for ImmunoTherapy of Cancer 10.1136/jitc-2025-013668 Humans, Immunity, Innate, Adaptive Immunity, Neoplasms, Receptors, Antigen, T-Cell, gamma-delta, Animals, T-Lymphocytes, Adaptive, Education, Immunotherapy, Innate, T-Lymphocytes yes Solé Casaramona, Arnau; Bachmann, Martin F; Sevick-Muraca, Eva; et al., "γδ T Cells at the Interface of Innate and Adaptive Immunity in Cancer" (2026). The Brown Foundation: Institute of Molecular Medicine. 72.

Introduction γδ T-cell overview The concept of innate versus adaptive immunity was developed during the first half of the 20th century and has guided immunological research for multiple decades.1 However, recent discoveries of new immune populations have challenged this binary classification, like γδ T cells.1 These immune cells have demonstrated a dual nature by using innate pattern recognition alongside rapid effector functions and adaptive features including antigen specificity, clonal...