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Arnelle Löbbert on Muck Rack

Arnelle Löbbert

As seen in: Wiley Online Library, BioRxiv
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Articles

Human cells for human proteins: Isotope labeling in mammalian cells in suspension for functional NMR studies

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By Philip Rößler, Marco M. Ruckstuhl, Arnelle Löbbert
| Wiley Online Library Verified
1 INTRODUCTION To understand human biology and disease, examining human proteins at the molecular level gives insights into their function and interactions, and ultimately can lead to ways of treating a disease using novel therapeutic molecules.
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GRKs phosphorylate GPCR C-terminal peptides in a hierarchical manner

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By Nils Lorz, Philip Rößler, Carsten Hoffmann, Arnelle Löbbert
| BioRxiv
Abstract Responses from G protein-coupled receptors (GPCRs) are downregulated in a precisely orchestrated process called desensitization. This process consists of two major steps: phosphorylation of the receptor by GPCR kinases (GRKs), predominantly on its C-terminus, and recruitment of arrestin, resulting in different signaling outcomes.
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