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Discussion In this work, we promote a two-sided interpretation of a biomarker analysis, one regarding the potential use of biomarkers for future streamline diagnosis tests and a second one revolving around the representation of a dysregulated immune response reflected by unbalanced biomarkers. The results we obtained enabled the isolation of five immune biomarkers namely ICAM.1, VCAM.1, G.CSF, CXCL10, and TNF- α.
Highlight • The RECOVERY trial reported that convalescent plasma had no effect on mortality in COVID-19 • A re-analysis of the data using Bayesian methods suggests there is a real possibility of benefit • The probability of any benefit of plasma in seronegative patients in this trial is more than 75% Introduction Convalescent plasma (CP) – blood components from patients recovered from an infection - has been used for more than a century to treat infections, with widespread use in the 1920’s...
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