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Abstract Celiac disease (CeD) is an autoimmune disorder triggered by dietary gluten. While HLA-DQ2/8-mediated presentation of gliadin peptides is required for disease, the mechanisms that underlie the loss of oral tolerance to gluten remain incompletely understood. Long-noncoding RNAs (lncRNAs) have been increasingly recognized as regulators of immune function, yet their role in oral tolerance has not been previously explored.
Keywords immunosuppressive neutrophil MDSC polymorphonuclear myeloid-derived suppressor cells gastric cancer TFF2 CXCR4 granulopoiesis partial agonist Get full text access Log in, subscribe or purchase for full access. References 1. Veglia, F. ∙ Sanseviero, E. ∙ Gabrilovich, D.I. Myeloid-derived suppressor cells in the era of increasing myeloid cell diversity Nat. Rev. Immunol. 2021; 21:485-498 2. van Vlerken-Ysla, L. ∙ Tyurina, Y.Y. ∙ Kagan, V.E. ...
The immune system can mount T cell responses against tumors; however, the antigen specificities of tumor-infiltrating lymphocytes (TILs) are not well understood. We used yeast-display libraries of peptide-human leukocyte antigen (pHLA) to screen for antigens of “orphan” T cell receptors (TCRs) expressed on TILs from human colorectal adenocarcinoma. Four TIL-derived TCRs exhibited strong selection for peptides presented in a highly diverse pHLA-A∗02:01 library.
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